THE MANNICH REACTION IN THE SYNTHESIS OF N,S-CONTAINING HETEROCYCLES. 7. EFFECTIVE ONE-POT SYNTHESIS OF DERIVATIVES OF SPIRO[3,5,7,11-TETRAAZATRICYCLO [7.3.1.0<sup>2,7</sup>]TRIDEC-2-ENE-13,4′-PIPERIDINE]
DOI:
https://doi.org/10.1007/7345Keywords:
10-amino-9-aza-3-azonia-7, 11-dicyano-3-isopropylspiro[5, 5]undeca-7, 1-diene-8-thiolate, pyridine-2-thiolates, spiro[3, 5, 7, 11]-tetraazatricyclo[7.3.1.0<sup>2, 7</sup>]tridec-2-ene-13, 4'-piperidine]-1, 9-dicarbonitrile, aminomethylation, the Mannich reaction, cyclocondensationAbstract
5,11-Disubstituted derivatives of 1'-isopropyl-8-thioxospiro[3,5,7,11-tetrazatricyclo[7.3.1.0<sup>2,7</sup>]tridec-2-ene-13,4′-piperidine]-1,9-dicarbonitrile was obtained by the interaction of 10-amino-9-aza-3-azonia-7,11-dicyano-3-isopropylspiro[5,5]undeca-7,10-diene-8-thiolate with 2 equiv. of a primary amine and excess of formaldehyde. An anomalous reaction product was obtained with o-toluidine – 7,9-dicyano-1′-isopropyl-3-(2-methylphenyl)-1,2,3,4-tetrahydrospiro[pyrido[1,2-a][1,3,5]triazine-8,4′-piperidinium]-6-thiolate.
How to Cite
Dotsenko, V. V.; Krivokolysko, S. G.; Litvinov, V. P. Chem. Heterocycl. Compd. 2007, 43, 1455. [Khim. Geterotsikl. Soedin. 2007, 1709.]
For this article in the English edition see DOI 10.1007/s10593-007-0224-5
