SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL N-SUBSTITUTED 4-AMINO-6,7,8-TRIMETHOXYQUINAZOLINE COMPOUNDS

Authors

  • Gang Liu School of Chemistry and Materials Science, Ludong University, Yantai 264025
  • Chunping Liu School of Chemistry and Materials Science, Ludong University, Yantai 264025
  • Lin Sun School of Chemistry and Materials Science, Ludong University, Yantai 264025
  • Rongjun Qu School of Chemistry and Materials Science, Ludong University, Yantai 264025
  • Hou Chen School of Chemistry and Materials Science, Ludong University, Yantai 264025
  • Chunnuan Ji School of Chemistry and Materials Science, Ludong University, Yantai 264025

DOI:

https://doi.org/10.1007/7370

Keywords:

gallic acid, quinazoline, anticancer

Abstract

A series of  N-substituted  4-amino-6,7,8-trimethoxyquinazoline derivatives has been synthesized from 4-chloro-6,7,8-trimethoxyquinazoline  and aryl (or benzyl) amines using 2-propanol as a solvent. The starting material  4-chloro-6,7,8-trimethoxyquinazoline has  been synthesized from natural gallic acid by a novel route. Their structures have been verified by elemental analysis, IR, 1H and 13C NMR spectroscopy. The title compounds have been evaluated for their  in vitro antiproliferative activities against some cancer cells by the MTT method. Unfortunately, most of the compounds tested have exhibited a weaker anticancer activity than the reference standard drug PD153035.

How to Cite
Liu, G.; Liu, C.; Sun, L.; Qu, R.; Chen, H.; Ji, C.  Chem. Heterocycl. Compd. 2007, 43, 1290. [Khim. Geterotsikl. Soedin. 2007, 1521.]

For this article in the English edition see DOI 10.1007/s10593-007-0196-5

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Published

2023-01-25

Issue

No. 10 (2007)

Section

Original Papers