SYNTHESIS OF 2-PYRIDYL-SUBSTITUTED DERIVATIVES OF 7-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[3,4-<i>d</i>]PYRIMIDINE

Authors

  • А. Ю. Кузнецов Institute for Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region
  • С. В. Чапышев Institute for Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region

DOI:

https://doi.org/10.1007/7374

Keywords:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate, pyridinecarboxyamidines, pyrido[3, 4-d]pyrimidines, condensation

Abstract

A method has been developed for the synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine based on the condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with pyridyl-2-, pyridyl-3-, and pyridyl-4-carboxamidines and subsequent reactions of 7-benzyl-2-pyridyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-ones with trifluoromethanesulfonic anhydride and secondary amines.

How to Cite
Kuznetsov, A. Yu.; Chapyshev, S. V.  Chem. Heterocycl. Compd. 2007, 43, 1320. [Khim. Geterotsikl. Soedin. 2007, 1556.]

For this article in the English edition see DOI 10.1007/s10593-007-0200-0


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Published

2023-01-26

Issue

No. 10 (2007)

Section

Original Papers