SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW HOMO ACYCLIC NUCLEOSIDES, 1-(PENT-4-ENYL)QUINOXALIN-2-ONES AND 2-(PENT-4-ENYLOXY)QUINOXALINES

Authors

  • I. A. I. Ali Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia
  • I. A. Al-Masoudi College of Veterinary Medicine, University of Basrah, Basrah
  • H. Gh. Hassan College of Science, Department of Chemistry, University of Sulaimania
  • N. A. Al-Masoudi Fachbereich Chemie, Universität Konstanz, Postfach 5560, D-78457 Konstanz, Germany

DOI:

https://doi.org/10.1007/7426

Keywords:

acyclonucleosides, glycosides, quinoxalines, alkylation, antiviral activity

Abstract

A series of acyclonucleosides 6,7-disubstituted  1-(pent-4-enyl)quinoxalin-2-one derivatives and the O-analogs were synthesized by a one-step condensation of the corresponding quinoxaline bases with 5-bromo-1-pentene. Acyclonucleosides prepared were assayed against HIV-1 and HIV-2 in MT-4 cells. 6,7-Dimethyl-2-(pent-4-enyloxy)quinoxaline showed inhibition of HIV-1
with EC50 value of 0.22 ± 0.08 µg/ml and a therapeutic index of 13. This means that it was cytotoxic to MT-4 cells at CC50 of 2.6 ± 0.1 µg/ml.

How to Cite
Ali, I. A. I.; Al-Masoudi, I. A.; Hassan, H. Gh.; Al-Masoudi, N. A.  Chem. Heterocycl. Compd. 2007, 43, 1052. [Khim. Geterotsikl. Soedin. 2007, 1243.]

For this article in the English edition see DOI 10.1007/s10593-007-0164-0

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Published

2023-02-02

Issue

No. 8 (2007)

Section

Original Papers