SYNTHESIS AND CYTOTOXICITY OF METAL 4-METHYL-8-QUINOLINETHIOLATES

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Ященко Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Зарума RTU Institute of Inorganic Chemistry, Salaspils, LV-2169
  • Я. Ашакс RTU Institute of Inorganic Chemistry, Salaspils, LV-2169

DOI:

https://doi.org/10.1007/7529

Keywords:

4-methyl-8-quinolinethiolates of copper iridium, osmium, palladium, platinum, rhodium, ruthenium, synthesis, toxicity, cytotoxicity

Abstract

It has been shown that the introduction of a methyl group at position 4 of the quinoline ring in metal 8-quinolinethiolates brings about a significant  increase  in the selectivity of their cytotoxic activity. It was found that rhodium 4-methyl-8-quinolinethiolate is 46 times less toxic than  the  unsubstituted 8-quinolinethiolate but with comparable toxicity towards MG-22A tumor cells (LC50 2 µg/ml).

How to Cite
Lukevics, E.; Shestakova, I.; Domracheva, I.; Yashchenko, E.;  Zaruma, D.; Ashaks, J.  Chem. Heterocycl. Compd. 2007, 43, 634. [Khim. Geterotsikl. Soedin. 2007, 755.]

For this article in the English edition see DOI 10.1007/s10593-007-0098-6


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Published

2023-03-21

Issue

No. 5 (2007)

Section

Original Papers