SYNTHESIS OF PYRIDO[3,4-<i>d</i>]PYRIMIDINES BY CONDENSATION OF ETHYL 1-BENZYL-3-OXOPIPERIDINE-4-CARBOXYLATE WITH MORPHOLINE-4-CARBOXAMIDINE

Authors

  • А. Ю. Кузнецов Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region
  • Н. Л. Нам K. A. Timiryazev Russian State Agrarian University, Moscow 127550
  • С. В. Чапышев Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region

DOI:

https://doi.org/10.1007/7531

Keywords:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate, morpholine-4-carboxamidine, pyrido[3, 4-d]pyrimidines, condensation

Abstract

A method has been developed for the synthesis of 4-amino-substituted 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine and subsequent reaction of the 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one with trifluoromethanesulfonic anhydride and secondary amines.

How to Cite
Kuznetsov, A. Yu.; Nam, N. L.; Chapyshev, S. V.  Chem. Heterocycl. Compd. 2007, 43, 640. [Khim. Geterotsikl. Soedin. 2007, 762.]

For this article in the English edition see DOI 10.1007/s10593-007-0100-3


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Published

2023-03-21

Issue

No. 5 (2007)

Section

Original Papers