PHASE-TRANSFER CATALYTIC SYNTHESIS AND HYPOCHOLESTEROLEMIC ACTIVITY OF THIAZINO[3,2-<i>a</i>]BENZIMIDAZOLE AND ITS SILICON ANALOG

Authors

  • Э. Абеле Lativian Institute of Organic Synthesis, Riga LV-1006
  • Р. Абеле Lativian Institute of Organic Synthesis, Riga LV-1006
  • П. Арсенян Lativian Institute of Organic Synthesis, Riga LV-1006
  • С. Беляков Lativian Institute of Organic Synthesis, Riga LV-1006
  • М. Веверис Lativian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Lativian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/7680

Keywords:

thiazino[3, 2-a]benzimidazole, hypocholesterolemic activity, phase-transfer catalysis

Abstract

The reaction of 2-mercaptobenzimidazole with 1,3-dichloropropane or bis(chloromethyl)dimethylsilane in  the  two-phase  catalytic system of solid K2CO3 – 18-crown-6 – toluene at 111oC leads to a selective formation of tricyclic benzimidazole sulfides in 56 and 92% yields. The synthesized compounds were tested as hypocholesterolemic agents.

How to Cite
Abele, E.; Abele, R.; Arsenyan, P.; Belyakov, S.; Veveris, M.; Lukevics, E.  Chem. Heterocycl. Compd. 2007, 43, 220. [Khim. Geterotsikl. Soedin. 2007, 274.]

For this article in the English edition see DOI 10.1007/s10593-007-0034-9


Downloads

Published

2023-04-04

Issue

No. 2 (2007)

Section

Original Papers