SYNTHESIS OF 3-SUBSTITUTED PYRROLIDINES

Authors

  • А. В. Куркин M. V. Lomonosov Moscow State University, Moscow
  • Е. А. Сумцова M. V. Lomonosov Moscow State University, Moscow
  • М. А. Юровская M. V. Lomonosov Moscow State University, Moscow

DOI:

https://doi.org/10.1007/7698

Keywords:

N-benzyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine, piperidines, reduction of pyridines, 1, 3-dipolar cycloaddition to alkenes

Abstract

A method was developed for the synthesis of derivatives of 3-substituted pyrrolidines from activated alkenes by 1,3-dipolar cycloaddition of unstable 2-benzylazomethylide, generated in situ from N-benzyl-N-(methoxymethyl)-N-(trimethylsilyl)amine. A  method was developed for the reduction of 4-(3-pyrrolidyl)pyridine, prepared by the above-mentioned method, to the corresponding derivatives of (3-pyrrolidyl)piperidine with high yields under mild conditions.

How to Cite
Kurkin, A. V.; Sumtsova, E. A.; Yurovskaya, M. A.  Chem. Heterocycl. Compd. 2007, 43, 34. [Khim. Geterotsikl. Soedin. 2007, 41.]

For this article in the English edition see DOI 10.1007/s10593-007-0005-1


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Published

2023-04-05

Issue

No. 1 (2007)

Section

Original Papers