4-HYDROXY-2-QUINOLONES. 108. N-R-AMIDES OF 9-FLUORO-1-HYDROXY-5-METHYL-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-<i>ij</i>]QUINOLINE-2-CARBOXYLIC ACID AND THEIR ANTITUBERCULAR ACTIVITY

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkiv 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv 61002
  • О. В. Шишкин Institute of Scintillation Materials, Ukraine National Academy of Sciences, Kharkiv 61001
  • А. В. Туров Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/7825

Keywords:

heterocyclic tricarbonylmethanes, 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid esters and amides, antitubercular activity, X-ray structural analysis

Abstract

The reaction of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline  with triethylmethanetricarboxylate gives di(9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinolin-2-yl)methane and ethyl 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate from which alkyl-, dialkylaminoalkyl-, and hetarylamides  as well as hydrazides were prepared. The structure and antitubercular properties of the compounds synthesized are discussed.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Shishkin, O. V.; Turov, A. V.  Chem. Heterocycl. Compd. 2006, 42, 1208. [Khim. Geterotsikl. Soedin. 2006, 1391.]

For this article in the English edition see DOI 10.1007/s10593-006-0228-6


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Published

2023-05-24

Issue

No. 9 (2006)

Section

Original Papers