SYNTHESIS AND REDUCTION OF 5-HALO- AND 5-NITRO-1-(BENZOFURAN-3-YL)-2-PHENYLETHANONES

Authors

  • H. Kwiecień Department of Organic Synthesis and Drug Technology, Szczecin University of Technology, 71-065 Szczecin
  • M. Szychowska Department of Organic Synthesis and Drug Technology, Szczecin University of Technology, 71-065 Szczecin

DOI:

https://doi.org/10.1007/7835

Keywords:

amines, benzofurans, ethanols, ethanones, acylation, reduction

Abstract

Novel 1-(2-alkylbenzofuran-3-yl)-2-(4-methoxyphenyl)ethanones having a halogen or nitro group  in position 5 of benzofuran ring were synthesized starting with the corresponding 2-(2-formylphenoxy)alkanoic acids. 1-(2-Alkylbenzofuran-3-yl)-2-phenylethanols containing bromine or chlorine atom were prepared in high yields by reduction of the corresponding ethanones with lithium aluminium hydride. Selective catalytic reduction of nitro 1-(2-alkylbenzofuran-3-yl)-2-(4-methoxyphenyl)ethanones to the corresponding amino compounds under Pd/C in  room temperature was achieved.

How to Cite
Kalvinsh, I.; Stradins, J.; Skorova, A.  Chem. Heterocycl. Compd. 2006, 42, 1. [Khim. Geterotsikl. Soedin. 2006, 1.]

For this article in the English edition see DOI 10.1007/s10593-006-0194-z

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Published

2023-05-25

Issue

No. 8 (2006)

Section

Original Papers