SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 2,3-DIARYL-4(3H)-QUINAZOLINONES

Authors

  • M. R. Yadav Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara-390 001
  • S. T. Shirude Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara-390 001
  • A. Parmar Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara-390 001
  • R. Balaraman
  • R. Giridhar Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara-390 001

DOI:

https://doi.org/10.1007/7842

Keywords:

4(3H)-quinazolinones, COX-2 inhibitors

Abstract

2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 µM concentration in  the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-nduced rat paw edema assay.

Как ссылаться
Yadav,  M. R.; Shirude, S. T.;  Parmar, A.; Balaraman, R.; Giridhar, R.  Chem. Heterocycl. Compd. 2006, 42, 1038. [Химия гетероцикл. соединений 2006, 1198.]

Статья в английском издании журнала: DOI 10.1007/s10593-006-0201-4

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Published

2023-05-26

Issue

No. 8 (2006)

Section

Original Papers