SYNTHESIS OF AZINYLTHIOUREAS AND THEIR HETEROCYCLIZATION USING α-CHLOROACETOACETIC ESTER

Authors

  • В. В. Довлатян Armenian Agricultural Academy, Yerevan 375009
  • К. А. Элиазян Armenian Agricultural Academy, Yerevan 375009
  • Э. А. Казарян Armenian Agricultural Academy, Yerevan 375009
  • А. П. Енгоян Armenian Agricultural Academy, Yerevan 375009

DOI:

https://doi.org/10.1007/8035

Keywords:

azinylthioureas, thiazole-5-carboxylic acid, heterocyclization

Abstract

Treatment of aminopyrimidines with a mixture of PhCOCl and NH4SCN and subsequent debenzoylation of the N-benzoyl-N'-(4,6-substituted pyrimidin-2-yl)thioureas  obtained gave pyrimidinyl-2-thioureas. The heterocyclization of the azinyl-2-thioureas with α-chloroacetoacetic ester gave  ethyl 2-(4,6-substituted azin-2-yl)aminothiazole-5-carboxylates.

How to Cite
Dovlatyan, V. V.; Eliazyan, K. A.; Ghazaryan, E. A.; Yengoyan, A. P.  Chem. Heterocycl. Compd. 2006, 42, 389. [Khim. Geterotsikl. Soedin. 2006, 437.]

For this article in the English edition, see DOI /10.1007/s10593-006-0097-z


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Published

2023-09-12

Issue

No. 3 (2006)

Section

Original Papers