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DISCOVERY OF INDOLE-3-ACETIC ACID DERIVATIVES CONTAINING 1,3,4-THIADIAZOLE THIOETHER AND AMIDE MOIETIES AS NOVEL ANTIBACTERIAL AGENTS

Authors

Chenghao Tang Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili
Jiali Shao School of Life and Health Science, Kaili University, Kaili
Chou Si School of Life and Health Science, Kaili University, Kaili
Xiumei Yang School of Life and Health Science, Kaili University, Kaili
Xiuhong Hu Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili
Pei Li Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili
Xiang Wang Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili

Keywords:

thioether, amide, plant bacterial disease, indole-3-acetic acid, 1,3,4-thiadiazole

Abstract

A series of twenty one novel compounds derived from indole-3-acetic acid, the structure of which includes 1,3,4-thiadiazole, thioether, and amide moieties were designed, synthesized, and evaluated for their in vitro antibacterial activity against three bacterial strains. The bioassay results showed that among the synthesized compounds, N-{5-[(2-fluorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-(1H-indol-3-yl)propanamide demonstrated the best inhibition rate against Pseudomonas syringae pv. actinidiae and N-{5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-(1H-indol-3-yl)propanamide possessed the best inhibition rate against Xanthomonas oryzae pv. oryzae and Xanthomonas axonopodis pv. citri, in all cases superior to that of bactericides thiodiazole copper and bismerthiazol.