AMBIDENTATE PROPERTIES OF ASYMMETRIC SUBSTITUTED IMIDAZOLES. DIRECTION OF BENZYLATION OF 2-[N-(4-CHLOROPHENYL)CARBAMOYL]METHYLTHIO-4-PHENYL-1H-IMIDAZOLE

Authors

  • А. Г. Иванова ASINEX, Moscow 123182
  • Р. В. Комбаров ASINEX, Moscow 123182
  • П. В. Давиденко ASINEX, Moscow 123182
  • О. Г. Родин ASINEX, Moscow 123182

DOI:

https://doi.org/10.1007/8276

Keywords:

imidazole-2-thiols, asymmetric substituted imidazoles, benzylation, 1H-1H two dimensional NMR spectroscopy (NOESY)

Abstract

On the basis of 1H-1H two dimensional NMR spectroscopy (NOESY) it has been unambiguously shown that the benzylation of 2-[N-(4-chlorophenyl)carbamoyl]methylthio-4-phenyl-1H-imidazole occurs at the N(1) atom. This data was confirmed by comparison of the properties of the alkylation product obtained with the corresponding N(3)-benzylimidazole isomer synthesized independently.

How to Cite
Ivanova, A. G.; Kombarov, R. V.; Davidenko, P. V.; Rodin, O. G.  Chem. Heterocycl. Compd. 2005, 41, 761. [Khim. Geterotsikl. Soedin. 2005, 882.]

For this article in the English edition, see DOI 10.1007/s10593-005-0217-1


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Published

2023-11-08

Issue

No. 6 (2005)

Section

Original Papers