A COMPARATIVE STUDY OF THE REACTIONS OF THIOPHENE-2-CARBOXANILIDES AND RELATED COMPOUNDS

Abstract

Thiophene-2-саrboxanilidе, its p-chloro and p-bromo derivatives react with chlorosulfonic acid to give the corresponding sulfonyl chlorides, which react with amino acids to give respective derivatives, several methyl esters of the latter were prepared. Hydrazinolysis of these methyl esters yielded the hydrazides. Coupling reactions of some sulfonylamino acids with amino acid methyl ester hydrochlorides in ТHF-Еt₃N medium using the dicyclohexylcarbodimide method give corresponding dipeptide methyl esters. The spectral data of the compounds are briefly discussed.

How to Cite
El-Sayed, R. A. Chem. Heterocycl. Compd. 1998, 34, 796. [Khim. Geterotsikl. Soedin. 1998, 34, 921.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02251685