RECENT ADVANCES IN THE SYNTHESIS OF THIAZOLO[4,5-<i>b</i>]PYRIDINES. PART 1: FOCUS ON PYRIDINE ANNULATION TO THIAZOLE RING

Authors

  • Taras I. Chaban Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010
  • Olena V. Klenina Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010. University San Pablo-CEU, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain
  • Ihor H. Chaban Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010
  • Maryan I. Lelyukh Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010

Keywords:

methods of synthesis, thiazolo[4,5-b]pyridines

Abstract

The present microreview systematizes recent advances in the synthetic approaches for novel thiazolo[4,5-b]pyridines and summarizes pharmacological effects they were found to possess. In particular, modern synthetic techniques for thiazolo[4,5-b]pyridine bicyclic scaffold construction starting from thiazole or thiazolidine derivatives followed by pyridine annulation, which results in the target fused thiazolo[4,5-b]pyridines, are analyzed.

Author Biographies

Taras I. Chaban, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010

PhD in pharmacy (2013), associate professor, Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University (2016). Field of scientific interests: organic synthesis, medicinal chemistry, high throughput screening, computational chemistry.

Olena V. Klenina, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010. University San Pablo-CEU, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain

PhD in pharmacy (2002), associate professor, Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University (2011); Field of scientific interests: computational chemistry, virtual screening, structure-based drug design, organic synthesis.

Ihor H. Chaban, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010

PhD in pharmacy (1991), associate professor, Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University (2001). Field of scientific interests: organic synthesis, medicinal chemistry, computational chemistry, virtual screening.

Maryan I. Lelyukh, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010

PhD in pharmacy (2017), senior lecturer, Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University (2019). Field of scientific interests: organic synthesis, medicinal chemistry, computational chemistry, virtual screening.

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Published

2024-03-26

Issue

Vol. 60 No. 1/2 (2024)

Section

Heterocycles in Focus