Synthesis of 4-alkyl-substituted 1,2,3,4-tetrahydropyrimidin-2-ones by the Biginelli reaction

Authors

  • А. Д. Шуталев M. V. Lomonosov State Academy of Fine Chemical Technology, Moscow 117571
  • Н. B. Сивова M. V. Lomonosov State Academy of Fine Chemical Technology, Moscow 117571

Abstract

p-Toluenesulfinic acid is an effective catalyst for condensation of acetoacetic ester with urea and aliphatic or aromatic aldehydes, leading to formation of 4-substituted 6-methyl-5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidin-2-ones.

How to Cite
Shutalev, A. D.; Sivova, N. V. Chem. Heterocycl. Compd. 1998, 34, 848. [Khim. Geterotsikl. Soedin. 1998, 34, 979.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02251695

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Published

1998-07-25

Issue

No. 7 (1998)

Section

Original Papers