CONDENSED ISOQUINOLINES. 17. ENAMINE PROPERTIES OF BENZIMIDAZO[1,2-<i>b</i>]ISOQUINOLIN-11(5H)-ONE IN ALKYLATION REACTIONS

Authors

  • L. M. Potikha Taras Shevchenko National University, Kiev 01033
  • N. V. Shkilna Taras Shevchenko National University, Kiev 01033
  • V. M. Kisil Taras Shevchenko National University, Kiev 01033
  • V. A. Kovtunenko Taras Shevchenko National University, Kiev 01033

Keywords:

heterocyclic enamines, derivatives of 1,6-dihydro-11H-6a,11b-diazabenzo[b]benzo[5,6]cyclohepta[1,2,3-l,m]fluoren-11-one and spiro[benzimidazo[1,2-b]isoquinolin-6,2'-indan]-11-one, alkylation

Abstract

The alkylation of benzimidazo[1,2-b]isoquinolin-11(5H)-one has been studied. This occurs at N(5) or C(6)
depending on the type of alkylating agent and the reaction conditions. It was shown that C(6) alkylation is effected in reactions with reactive alkyl halides. A repeat alkylation occurs preferentially at the same position. Interaction with o-xylylidene dibromide leads to spiro[benzimidazo[1,2-b]-isoquinolin-6,2'-indan]-11-one and 1,6-dihydro-11H-6a,11b-diazobenzo[b]benzo[5,6]cyclohepta-[1,2,3-l,m]fluoren-11-one, which are derivatives of new heterocyclic systems.

How to Cite
Potikha, L. M.; Shkilna, N. V.; Kisil, V. M.; Kovtunenko, V. A Chem. Heterocycl. Compd. 2004, 40, 1052. [Khim. Geterotsikl. Soedin. 2004, 1214.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000046697.89737.65

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Published

2004-08-25

Issue

No. 8 (2004)

Section

Original Papers