SYNTHESIS OF 7-ALKYL-4-AMINO-7<i>H</i>-PYRROLO[2,3-<i>d</i>]PYRIMIDINE-6-CARBOXYLIC ACIDS

Authors

  • Е. В. Вервес Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine
  • А. В. Кучер Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine
  • Л. В. Музычка Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine
  • О. Б. Смолий Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.1007/859

Keywords:

ethyl N-alkylglycinate, pyrimido[5', 4', 4, 5]pyrrolo[2, 1-c][1, 4]oxazine, 7H-pyrrolo[2, 3-d]-pyrimidine, cyclization

Abstract

Two variants are discussed for the synthesis of ethyl N-alkyl-N-(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.

Authors: E. V. Verves, A. V. Kucher, L. V. Muzychka, and O. B. Smolii

English Translation in Chemistry of Heterocyclic Compounds, 2013, 48 (12), pp 1844-1852

http://link.springer.com/article/10.1007/s10593-013-1218-0

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Published

2013-08-21

Issue

No. 12 (2012)

Section

Original Papers