Synthesis of imidazo[2,1-<i>b</i>]thiazol-5-amines using Groebke–Blackburn–Bienaymé multicomponent reaction

Abstract

This microreview discusses the recent studies (last 10 years) on the synthesis of imidazo[2,1-b]thiazol-5amines using the Groebke–Blackburn–Bienaymé multicomponent reaction between 2-aminothiazoles, isocyanides, and aldehydes under different reaction and catalytic conditions.