Reaction of 6-methyl-2-methylthio-3-(2-thioxo-1,3,4-oxadiazol-5-yl)methyl-4(3H)-pyrimidinone with amines

Abstract

The reaction of 6-methyl-2-methylthio-3-(2-thioxo-1,3,4-oxadiazol-5-yl)methyl-4(3H)-pyrimidinone with butyland benzylamine and also with piperidine and morpholine has been studied. It was found that the primary amines not only open the 1,3,4-oxadiazole ring to form the corresponding thiosemicarbazides but also substitute the methylthio group at position 2 in the pyrimidine ring. Morpholine can only open the 1,3,4-oxadiazole ring but piperidine can also substitute the methythio group to give an oxadiazolethione piperidinium salt.

How to Cite
Yakubkene, V.; Vainilavichyus, P. Chem. Heterocycl. Compd. 1998, 34, 971. [Khim. Geterotsikl. Soedin. 1998, 34, 1125.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02311335