RECENT ADVANCES IN THE CHEMISTRY OF PYRROLIDINE-2,3-DIONES

Authors

  • Semen S. Bondarenko Enamine Ltd., 78 Winston Churchill St., Kyiv 02094, Ukraine; Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01033, Ukraine https://orcid.org/0009-0003-5540-810X
  • Dmitry A. Lega Enamine Ltd., 78 Winston Churchill St., Kyiv 02094, Ukraine; Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01033, Ukraine https://orcid.org/0000-0002-4505-3646

Abstract

An overview of the most recent strategies for the construction of the pyrrolidine-2,3-dione platform, along with strategies toward its MedChem-relevant derivatives, is provided in this compilation. The microreview focuses on nonfunctionalized in positions 4 and 5 derivatives rather than well-reported 4-CO2R and 4-COR ones. The examples reported herein are arranged in three principal categories: assembly of the pyrrolidine-2,3-dione core, its functionalization, and the construction of sophisticated 3D chiral carcasses with high medicinal prospects based on the core. The summary includes works published within a period from 2020 to 2024.

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Published

2024-05-28

Issue

Vol. 60 No. 3/4 (2024)

Section

Heterocycles in Focus