An overview of the synthetic routes toward [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazoles

Abstract

Fused systems combining 1,2,4-triazole and 1,3,4-thiadiazole rings occupy a prominent place in modern bioorganic and medicinal chemistry due to the diverse range of their biological activities. Thus, compounds incorporating [1,2,4]triazolo[3,4-b]thiadiazole ring system are of essential importance and particular interest both in the pharmaceutical as well as agrochemical industries. Herein, an overview of certain synthetic methodologies for obtaining of heterocyclic compounds based on functionally substituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles are presented.