SYNTHESIS AND PROPERTIES OF <i>sym</i>-TRIAZINE DERIVATIVES. 18. SYNTHESIS OF N-SUBSTITUTED 2,4-DIAMINO-6-(BENZOTHIAZOLYL-2-THIOMETHYL)-<i>sym</i>-TRIAZINES
Keywords:
benzothiazole, biguanides, 2,4-diamino-sym-triazines, condensationAbstract
The condensation of methyl benzothiazolyl-2-thioacetate with N-substituted biguanides in the presence of sodium methylate gave 2-amino-4-(RR'-amino)-6-(benzothiazolyl-2-thiomethyl)-sym-triazines. In a number of cases the 1,1-disubstituted 5-(benzothiazolyl-2-thioacetyl)biguanides could also be separated and these could be cyclized by refluxing in DMF to the corresponding substituted sym-triazines described. The latter type of compound was also synthesized by treating 2-amino-4-trichloromethyl-6-(benzothiazolyl-2-thiomethyl)-sym-triazine with primary and secondary aliphatic and heterocyclic amines or by the reaction of N-substituted 2,4-diamino-6-chloromethyl-sym-triazines with 2-mercaptobenzothiazole.
How to Cite
Kelarev, V. I.; Silin, M. A.; Borisova, O. A. Chem. Heterocycl. Compd. 2003, 39, 632. [Khim. Geterotsikl. Soedin. 2003, 730.]
For this article in the English edition, see DOI https://doi.org/10.1023/A:1025102300933
