SYNTHESIS OF DERIVATIVES OF PYRAZOLO[3,4-<i>d</i>]PYRIMIDINES BY REACTION OF 3,5-BIS(DIMETHYLAMINOMETHYLENE)AMINO-4-METHOXYCARBONYLPYRAZOLE AND 4-CYANOPYRAZOLE WITH AMINES

Authors

  • В. А. Макаров NIOPIK State Science Center of the Russian Federation, Moscow 103787
  • О. Б. Рябова NIOPIK State Science Center of the Russian Federation, Moscow 103787
  • Л. М. Алексеева NIOPIK State Science Center of the Russian Federation, Moscow 103787
  • А. С. Шашков N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • В. Г. Граник NIOPIK State Science Center of the Russian Federation, Moscow 103787

Keywords:

allopurinol, DMF acetal, 4-methoxycarbonylpyrazole, pyrazolo[3,4-d]pyrimidine, 4-cyanopyrazole

Abstract

The reaction of 3,5-di(N,N-dimethylaminomethylene)amino-4-methoxycarbonylpyrazole and 3,5-di(N,N-dimethylaminomethylene)amino-4-cyanopyrazole with different amines occurs with formation of pyrazolo[3,4-d]pyrimidines. In some reactions, an excess of amines leads to their conversion to N,N-dimethylformamidine derivatives. The structure of the compounds obtained has been confirmed by 1H NMR and 13C spectroscopy.

How to Cite
Makarov, V. A.; Ryabova, O. B.; Alekseeva, L. M.; Shashkov, A. S.; Granik, V. G. Chem. Heterocycl. Compd. 2003, 39, 238. [Khim. Geterotsikl. Soedin. 2003, 268.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023780710982

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Published

2003-02-25

Issue

No. 2 (2003)

Section

Original Papers