CONDITIONS FOR THE HETEROCYCLIZATION OF O-AROYL-β-MORPHOLINOPROPIOAMIDE OXIMES TO 5-ARYL-3-(β-MORPHOLINO)ETHYL-1,2,4-OXADIAZOLES

Authors

  • Л. А. Каюкова A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science, Republic of Kazakhstan, Almaty 480100

Keywords:

β-aminopropioamide oximes, O-aroyl-β-morpholinopropioamide oximes, 5-aryl-3-(β-morpholino)ethyl-1,2,4-oxadiazoles, slow inversion, 1H NMR spectroscopy

Abstract

A search has been made for the conditions of heterocyclization of O-aroyl-β-morpholinopropioamide oximes to 5-aryl-3-(β-morpholino)ethyl-1,2,4-oxadiazoles. We have investigated the heating of the starting compounds above their melting point, at their melting point, and holding in polar solvents (DMSO and DMF). Heating the O-aroylamide oxime hydrochlorides in DMF appeared optimal.

How to Cite
Kayukova, L. A. Chem. Heterocycl. Compd. 2003, 39, 223. [Khim. Geterotsikl. Soedin. 2003, 253.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023724626003

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Published

2003-02-25

Issue

No. 2 (2003)

Section

Original Papers