SYNTHESIS OF 3,4-DIHYDROBENZO[<i>h</i>]ISOQUINOLINE DERIVATIVES

Authors

  • Ю. В. Шкляев Institute of Technical Chemistry, Urals Branch of the Russian Academy of Sciences, Perm
  • Ю. В. Нифонтов Institute of Technical Chemistry, Urals Branch of the Russian Academy of Sciences, Perm

Keywords:

3,4-dihydrobenzo[h]isoquinolines, 1,2-dimethyl-1-(2-naphthyl)-1-propanol, nitriles, Ritter reaction

Abstract

1-Substituted 3,3,4-trimethyl-3,4-dihydrobenzo[h]isoquinolines have been obtained by the reaction of 1,2-dimethyl-1-(2-naphthyl)-1-propanol with nitriles in conc. H2SO4. It was shown that the presence of a benzene ring annelated at positions 7 and 8 of the isoquinoline does not influence reaction of the 1-methyl derivative with isocyanate, however reactions of the 1-methylthio derivative with C and N nucleophiles are affected significantly.

How to Cite
Shklyaev, Yu. V.; Nifontov,Yu. V. Chem. Heterocycl. Compd. 2003, 39, 184. [Khim. Geterotsikl. Soedin. 2003, 212.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023712223277

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Published

2003-02-25

Issue

No. 2 (2003)

Section

Original Papers