SYNTHESIS OF DERIVATIVES OF 2-(INDOL-1-YL)PROPIONIC ACIDS

Authors

  • А. В. Куркин M. V. Lomonosov Moscow State University, Moscow 119234
  • Н. Е. Голанцов M. V. Lomonosov Moscow State University, Moscow 119234
  • А. В. Карчава M. V. Lomonosov Moscow State University, Moscow 119234
  • М. А. Юровская M. V. Lomonosov Moscow State University, Moscow 119234

Keywords:

N-amino-N-phenylalanine esters, 2-(indol-1-yl)propionic acid esters, N-phenylalanine esters, reduction of N-nitrosamines, Fischer cyclization

Abstract

We have developed a method for synthesis of N-substituted derivatives of indole from N-phenylalanine, including Fischer cyclization of the corresponding arylalkylhydrazones. The starting hydrazines were obtained by reduction of the corresponding nitrosamines. We have established that the optimum reduction method is to use metallic zinc in a methanol–hydrochloric acid system at low temperatures.

How to Cite
Kurkin, A. V.; Golantsov, N. E.; Karchava, A. V.; Yurovskaya, M. A. Chem. Heterocycl. Compd. 2003, 39, 74. [Khim. Geterotsikl. Soedin. 2003, 78.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023072709260

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Published

2003-01-25

Issue

No. 1 (2003)

Section

Original Papers