SYNTHESIS OF CONDENSED FURAN STRUCTURES BASED ON 1-ARYL-3-BROMO-3-NITROPROPENONES

Authors

  • Ivan S. Adyukov Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg 191186
  • Vasilii V. Pelipko Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg 191186 https://orcid.org/0000-0003-1885-7005
  • Igor A. Litvinov A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center ''Kazan Scientific Center of the Russian Academy of Sciences'', 8 Akademika Arbuzova St., Kazan 420088
  • Oussama A. Mammeri Chemical Analysis and Materials Research Center, Saint Petersburg State University, 26 Universitetskii Ave., Petergof, Saint Petersburg 198504
  • Ruslan I. Baichurin Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg 191186
  • Sergey V. Makarenko Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg 191186

Keywords:

heterocycles, furan, halonitroalkene, CH-acid, nucleophilic addition

Abstract

This study presents an efficient method for the synthesis of condensed 3-aroyl-containing furan heterocycles, which are notable for their diverse biological activity, including antibacterial, antifungal, anti-inflammatory, and anticancer. The proposed method involves reaction of 1-aryl-3-bromo-3-nitropropenones with cyclic CH acids, yielding 3-aroyldihydrobenzofuran-4(5H)-ones and 3-aroyl-4H-furo[3,2-c]chromen-4-ones in excellent yields, providing a valuable approach for developing new biologically active compounds.

Author Biography

Vasilii V. Pelipko, Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg 191186

Старший научный сотрудник лаборатории нитросоединений РГПУ им. А. И. Герцена

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Published

2024-12-13

Issue

Vol. 60 No. 9/10 (2024)

Section

Original Papers