REACTION OF 2-(4-ARYLTHIAZOL-2-YL)-4-CHLORO-3-OXOBUTYRONITRILES WITH SECONDARY ALIPHATIC AMINES

Authors

  • Ю. М. Воловенко Taras Shevchenko Kiev National University, Kiev 252601
  • Т. А. Воловненко Taras Shevchenko Kiev National University, Kiev 252601
  • А. В. Твердохлебов Taras Shevchenko Kiev National University, Kiev 252601

Keywords:

4-aryl-2-cyanomethylthiazoles, 2-(4-arylthiazol-2-yl)-4-chloro-3-oxobutyronitriles, 3-aryl-7-cyano-6(5H)-oxopyrrolo[2,1-b]thiazoles, 4-dialkylamino-2-(4-arylthiazol-2-yl)-3-oxobutyronitriles, α-chloroacetyl chloride

Abstract

We have obtained 2-(4-arylthiazol-2-yl)-4-chloro-3-oxobutyronitriles by acylation of 4-aryl-2-cyanomethylthiazoles with α-chloroacetyl chloride. We have studied their reaction with secondary aliphatic amines, leading to formation of 4-dialkylamino-2-(4-arylthiazol-2-yl)-3-oxobutyronitriles, and also intramolecular alkylation with formation of 3-aryl-7-cyano-6(5H)-oxopyrrolo[2,1-b]thiazoles. We have determined some aspects of the tautomerism of the synthesized compounds.

How to Cite
Volovenko, Yu. M.; Volovnenko, T. A.; Tverdokhlebov, A. V. Chem. Heterocycl. Compd. 2001, 37, 1011. [Khim. Geterotsikl. Soedin. 2001, 1101.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1012747903598

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Published

2001-08-25

Issue

No. 8 (2001)

Section

Original Papers