SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS DERIVED FROM 3-FORMYLCHROMONES AND THEIR ANTIMICROBIAL EVALUATION

Authors

  • A. Bari Research Center, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia
  • S. S. Ali Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia
  • A. Kadi Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia
  • I. Ali Hashmi Department of Chemistry, University of Karachi, Karachi, Pakistan
  • S. W. Ng Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.1007/975

Keywords:

3-formylchromone, pyranopyrones, antimicrobial activity, enzyme inhibitors, Knoevenagel–Cope reaction, pharmacophore, urease inhibitory

Abstract

The synthesis and antimicrobial evaluation of a series of various chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel–Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused system. Most of the compounds exhibit good antimicrobial properties.

How to Cite
Bari, A.; Ali, S. S.; Kadi, A.; Hashmi, I. A.; Ng, S. W. Chem. Heterocycl. Compd. 2014, 49, 1723. [Khim. Geterotsikl. Soedin. 2013, 1860.]

For this article in the English edition see DOI 10.1007/s10593-014-1424-4

 

Author Biographies

A. Bari, Research Center, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia

Assistant Professor

S. S. Ali, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia

Assiatant Professor

A. Kadi, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box: 2457, Riyadh, 11451, Saudi Arabia

Associate Professor

I. Ali Hashmi, Department of Chemistry, University of Karachi, Karachi, Pakistan

Assistant Professor

S. W. Ng, Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

Professor

Downloads

Published

2013-10-31

Issue

No. 12 (2013)

Section

Original Papers