4-HYDROXY-2-QUINOLONES. 47. SYNTHESIS AND DIURETIC ACTIVITY OF (2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-YL)METHYLAMIDES OF 1R-4-HYDROXY-2-OXOQUINOLINE-3-CARBOXYLIC ACIDS

Authors

  • С. Г. Таран National Pharmaceutical Academy of the Ukraine, Kharkov 310002
  • И. В. Украинец National Pharmaceutical Academy of the Ukraine, Kharkov 310002
  • Н. В. Лиханова National Pharmaceutical Academy of the Ukraine, Kharkov 310002
  • О. В. Горохова National Pharmaceutical Academy of the Ukraine, Kharkov 310002
  • П. А. Безуглый National Pharmaceutical Academy of the Ukraine, Kharkov 310002

Keywords:

benzothiadiazine, diuretics, carbostyril, 4-hydroxy-2-quinolone

Abstract

With the aim of investigating the relationship between chemical structure and biological activity we have synthesized and studied the effect of (2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)methylamides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids on kidney urinary output.

How to Cite
Taran, S. G.; Ukrainets, I. V.; Likhanova, N. V.; Gorokhova, O. V.; Bezugly, P. A. Chem. Heterocycl. Compd. 2001, 37, 237. [Khim. Geterotsikl. Soedin. 2001, 262.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1017527802266

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Published

2001-02-25

Issue

No. 2 (2001)

Section

Original Papers