INVESTIGATIONS OF IMIDAZOLES. 101. SYNTHESIS OF 2,3-DIHYDROIMIDAZO[1,2-<i>a</i>]PYRIMIDINE FROM 2-AMINOPYRIMIDINE

Authors

  • П. М. Кочергин Center for the Chemistry of Medicinals. All Russian Chemical-Pharmaceutical Science Research Institute, 119815 Moscow
  • И. А. Мазур Zaporozhe State Medicinal University, 330074 Zaporozhe
  • Г. К. Рогульченко Zaporozhe State Medicinal University, 330074 Zaporozhe
  • Е. В. Александрова Zaporozhe State Medicinal University, 330074 Zaporozhe
  • Б. Е. Мандриченко Zaporozhe State Medicinal University, 330074 Zaporozhe

Keywords:

2-aminopyrimidine, 1,2-dibromoethane, dihydroimidazopyrimidine, imidazole, ethylene chloro(bromo)hydrin, cyclization

Abstract

Two novel preparative methods have been developed for the synthesis of 2,3-dihydroimidazo[1,2-a]-pyrimidine from 2-aminopyrimidine. These are the reaction with 1,2-dibromoethane and also the reaction with ethylene chloro(bromo)hydrin, subsequent treatment of 1-β-hydroxyethyl-2-imino-1,2-dihydropyrimidine with thionyl chloride, and cyclization of the intermediate 1-β-chloroethyl-2-imino-1,2-dihydropyrimidine in the presence of sodium hydroxide.

How to Cite
Kochergin, P. M.; Mazur, I. A.; Rogul'chenko, G. K.; Aleksandrova, E. V.; Mandrichenko, B. E. Chem. Heterocycl. Compd. 2001, 37, 224. [Khim. Geterotsikl. Soedin. 2001, 251.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1017571617287

 

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Published

2001-02-25

Issue

No. 2 (2001)

Section

Original Papers