A AMINOURACILS IN THE SYNTHESIS OF HETEROCYCLES

Authors

  • Rogheyeh Hossein Nia Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, P. O. Box 41335-1914, Rasht
  • Manouchehr Mamaghani Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, P. O. Box 41335-1914, Rasht
  • Fatame Tavakoli Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, P. O. Box 41335-1914, Rasht
  • Elham Saberikhah Caspian Faculty of Engineering, College of Engineering, University of Tehran, P.O. Box 43841-119, Guilan, Rezvanshar
  • Zahra Taati Department of Chemistry, University of Houston, 3585, Cullen Boulevard, Houston, TX 77204-5003

Keywords:

6-aminouracils, heterocycle, pyrimidine, thiouracil, uracil, multicomponent reaction, synthesis

Abstract

6-Aminouracil and its derivatives as a versatile reactant are applied for the formation of heterocyclic compounds with biological and pharmacological properties. The present review addresses the recent research in the synthesis of heterocycles using 6-aminouracil and thiouracil derivatives as starting compounds for the period of 2014–2024. Reports were categorized based on the type of target heterocycle  such as pyridopyrimidine, pyrimidopyrimidine, pyrimidoquinoline, pyranopyrimidine derivatives, etc. The main aim of this review is to provide a summary of recently reported procedures for the synthesis of fused heterocycles with uracil framework for organic and medicinal chemists.

Published

2026-05-15

Issue

Vol. 61 No. 11/12 (2025)

Section

Review Articles