SYNTHESIS OF SOME NOVEL BENZYLIDENEHYDANTOINS: AMINO ACIDS DERIVATIVES

Authors

  • Ragab A. El-Sayed Chemistry Department, Faculty of Science, Al-Azhar University Nasr-City, Cairo

Keywords:

5-(p-chlorosulfonylbenzylidene)hydantoin, N-[(p-hydantoinylidenemethyl)benzenesulfonyl] derivatives of amino acids, and dipeptides

Abstract

5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the corres-ponding p-sulfonyl chloride. Condensation of the latter with amino acids leads to sulfonylamino acid derivatives, which on coupling with glycine methyl ester hydrochloride in THF-Et3N using dicyclohexylcarbodiimide method furnish the desired dipeptide methyl esters. The spectral data of the compounds are briefly discussed.

How to Cite
El-Sayed, R. A. Chem. Heterocycl. Compd. 2001, 37, 91. [Khim. Geterotsikl. Soedin. 2001, 95.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1017592817982

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Published

2001-01-25

Issue

No. 1 (2001)

Section

Original Papers