Antibacterial glycopeptide antibiotics

Authors

  • М. Н. Преображенская Institute of Research into New Antibiotics, RAMN, Moscow
  • O. B. Мирошникова Institute of Research into New Antibiotics, RAMN, Moscow
  • А. Ю. Павлов Institute of Research into New Antibiotics, RAMN, Moscow
  • E. Н. Олсуфьева Institute of Research into New Antibiotics, RAMN, Moscow

Abstract

The structures of the most important antibacterial glycopeptide antibiotics and the mechanisms of their activity and resistance to them are examined. Researches on the total synthesis of antibiotics and model compounds are discussed. The chemical modification of antibiotics (changing the amino acid composition) and also the modification of fragments of the molecule that do not take part in interaction with the target but make it possible to overcome the resistance of bacteria to antibiotics of this group are discussed.

How to Cite
Preobrazhenskaya, M. N.; Miroshnikova, O. V.; Pavlov, A. Y.; Olsuf'eva, E. N. Chem. Heterocycl. Compd. 1998, 34, 1359. [Khim. Geterotsikl. Soedin. 1998, 1605.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02317806

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Published

1998-12-25

Issue

No. 12 (1998)

Section

Review Articles