STUDIES ON MONOBACTAMS. II. SYNTHESIS AND β-LACTAMASE INHIBITORY ACTIVITY OF 4α-METHYL-3-[(THIEN-2-YL)-METHYLENE]-2-AZEТIDINONE-1-SULFONATE

Authors

  • Oludotun A. Phillip SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Eduardo L. Setti SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Andhe V. N. Reddy SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Ronald G. Micetich SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Chieko Kunugita Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01
  • Akio Hyodo Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01
  • Samarendra N. Maiti SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2

Abstract

Two monobactam derivatives, potassium 4α-methyl-(ЗE)-[(thien-2- уl)methylene]-2-аzеtidinonе-1-sulfоnаtе and its  (ЗZ)-isomer, were prepared and evaluated for their β-lactamase inhibitory activities. These compounds were devoid of β-lactаmase inhibitory activity.

How to Cite
Phillips, O. A., Setti, E. L., Reddy, A. V. N.; Micetich, R. G.;  Kunugita, C.; Hyodo, A.; Maiti, S. N. Chem. Heterocycl. Compd. 1998, 34, 1319. [Khim. Geterotsikl. Soedin. 1998, 1548.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256812

Downloads

Published

1998-11-25

Issue

No. 11 (1998)

Section

Original Papers