STUDIES ON MONOBACTAMS. I. SYNTHESIS AND β-LACTAMASЕ INHIBITORY ACTIVITY OF 4-SUBSTITUTED 3-[(N-METHYL-1,2,3-TRIAZOL-4-YL)METHYLENE]-2-AZЕTIDINONЕ-1-SULFONATЕS

Authors

  • Oludotun A. Phillips SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • David P. Czajkowski SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Kevin Atchison SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Ronald G. Micetich SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Samarendra N. Maiti SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Chieko Kunugita Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01
  • Akio Hyodo Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01

Abstract

Two monobactam derivatives, potassium (ЗZ)-[(N-methyl-1,2,3-triazol-4-yl)methylene]-4-phеnуlthiо-2-azetidinоnе-1-sulfоnate and potassium (ЗЕ)-[(N-methyl-1,2,3-tгiаzоl-4-уl)mеthуlеnе]-4-(1,2,З-tгiаzоl-1-уl)-2-аzеtidinоnе-1-sulfonate, were synthesized and tested for β-lactamase inhibitory activity.

How to Cite
Phillips, O. A.; Czajkowski, D. P.; Atchison, K.; Micetich, R. G.; Maiti, S. N.; Kunugita, C.; Hyodo, A. Chem. Heterocycl. Compd. 1998, 34, 1308. [Khim. Geterotsikl. Soedin. 1998, 1536.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256811

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Published

1998-11-25

Issue

No. 11 (1998)

Section

Original Papers