Sulfones of 7-silyl- and 7-germylcephalosporanates

Authors

  • Г. Bейнберг Latvian Institute of Organic Synthesis, Riga LV-1006
  • M. Ворона Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Мусель Latvian Institute of Organic Synthesis, Riga LV-1006
  • Х. Кажока Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Страков Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

7-Silyl- and 7-germylcephalosporanates in the form of a mixture of 7α and 7β stereoisomers were prepared by the interaction of hydrosilanes and a hydrogermane* with sulfones of tert-butyl esters of 7-diazocephalosporanic acid and 7-diazodesacetoxycephalosporanic acid in the presence of rhodium diacetate. Some of the synthesized substances manifest cytotoxic effects in relation to tumor cells in vitro, and also inhibit the catalytic activity of the enzyme elastase.

How to Cite
Veinberg, G.; Vorona, M.; Mucel', D.; Kazhoka, Kh.; Shestakova, I.; Kanepe, I.; Domracheva, I.; Strakov, A.; Lukevitcs, E. Chem. Heterocycl. Compd. 1998, 34, 1276. [Khim. Geterotsikl. Soedin. 1998, 34, 1504.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256807

Downloads

Published

1998-11-25

Issue

No. 11 (1998)

Section

Original Papers