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ONE-STEP FACILE SYNTHESIS OF L-PROLINE ETHYLAMIDE HYDROCHLORIDE

A. N. Balaev, K. A. Okhmanovich, V. N. Osipov, V. E. Fedorov
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Abstract


One-step facile synthesis of a L-proline ethylamide  hydrochloride  
from L-proline in good yields via the cyclic silicon intermediate
is described. This is the first example of the efficient synthesis
of a alkylamide proline performed without protect-unprotect methods
and suitable for large scale preparation.

How to Cite
Balaev, A. N.; Okmanovich, K. A.; Osipov, V. N.; Fedorov, V. E. Chem. Heterocycl. Compd. 2014, 50, 287. [Khim. Geterotsikl. Soedin. 2014, 315.]

For this article in the English edition see DOI 10.1007/s10593-014-1474-7


Keywords


dichlorodimethylsilane; L-proline ethylamide; large scale preparation; one-step amidation, optimization

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