ONE-STEP FACILE SYNTHESIS OF L-PROLINE ETHYLAMIDE HYDROCHLORIDE

Авторы

  • A. N. Balaev Pharm-Sintez
  • K. A. Okhmanovich Pharm-Sintez
  • V. N. Osipov Pharm-Sintez
  • V. E. Fedorov Pharm-Sintez

DOI:

https://doi.org/10.1007/1434

Ключевые слова:

dichlorodimethylsilane, L-proline ethylamide, large scale preparation, one-step amidation, optimization

Аннотация

One-step facile synthesis of a L-proline ethylamide  hydrochloride  
from L-proline in good yields via the cyclic silicon intermediate
is described. This is the first example of the efficient synthesis
of a alkylamide proline performed without protect-unprotect methods
and suitable for large scale preparation.

How to Cite
Balaev, A. N.; Okmanovich, K. A.; Osipov, V. N.; Fedorov, V. E. Chem. Heterocycl. Compd. 2014, 50, 287. [Khim. Geterotsikl. Soedin. 2014, 315.]

For this article in the English edition see DOI 10.1007/s10593-014-1474-7

Биографии авторов

A. N. Balaev, Pharm-Sintez

Alexandr Balaev

K. A. Okhmanovich, Pharm-Sintez

Kirill Okhmanovich

V. N. Osipov, Pharm-Sintez

Vasily Osipov

V. E. Fedorov, Pharm-Sintez

Vladimir Fedorov

Опубликован

2014-02-28

Выпуск

Раздел

Письма в редакцию