Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF 5-TRIFLUOROACETYLPYRROLE- 2-CARBALDEHYDES

О. В. Петрова, М. В. Маркова, И. А. Ушаков, Л. Н. Собенина, Е. В. Третьяков, В. И. Овчаренко, А. И. Михалева, Б. А. Трофимов
Cover Image

Abstract


5-Trifluoroacetylpyrrole-2-carbaldehydes were synthesized by low-temperature trifluoroacetylation of pyrrole-2‑carbaldehyde acetals using trifluoroacetic anhydride, with subsequent removal of the acetal protecting group by mild acid-catalysed hydrolysis. The hydrolysis was accompanied by the formation of a minor product, (1Е,4Е)-1,5-bis[5-(2,2,2-trifluoroacetyl)-1Н‑pyrrol-2-yl]-1,4‑pentadien-3-one, which was isolated and identified.

How to Cite
Petrova, O. V.; Markova, M. V.; Ushakov, I. A.; Sobenina, L. N.; Tretyakov, E. V.; Ovcharenko, V. I.; Mikhaleva, A. I.; Trofimov, B. A. Chem. Heterocycl. Compd. 2014, 50, 941. [Khim. Geterotsikl. Soedin. 2014, 1022.]

For this article in the English edition see DOI 10.1007/s10593-014-1548-6


Keywords


pyrrole-2-carbaldehydes; trifluoroacetic anhydride; 5 trifluoroacetylpyrrole-2-carbaldehydes; acetal protecting groups; trifluoroacetylation

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv