SYNTHESIS OF 5-TRIFLUOROACETYLPYRROLE- 2-CARBALDEHYDES

Authors

  • О. В. Петрова Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • М. В. Маркова Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • И. А. Ушаков Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Л. Н. Собенина Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Е. В. Третьяков International Tomography Center, Siberian Branch, Russian Academy of Sciences
  • В. И. Овчаренко International Tomography Center, Siberian Branch, Russian Academy of Sciences
  • А. И. Михалева Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Б. А. Трофимов Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1766

Keywords:

pyrrole-2-carbaldehydes, trifluoroacetic anhydride, 5 trifluoroacetylpyrrole-2-carbaldehydes, acetal protecting groups, trifluoroacetylation

Abstract

5-Trifluoroacetylpyrrole-2-carbaldehydes were synthesized by low-temperature trifluoroacetylation of pyrrole-2‑carbaldehyde acetals using trifluoroacetic anhydride, with subsequent removal of the acetal protecting group by mild acid-catalysed hydrolysis. The hydrolysis was accompanied by the formation of a minor product, (1Е,4Е)-1,5-bis[5-(2,2,2-trifluoroacetyl)-1Н‑pyrrol-2-yl]-1,4‑pentadien-3-one, which was isolated and identified.

How to Cite
Petrova, O. V.; Markova, M. V.; Ushakov, I. A.; Sobenina, L. N.; Tretyakov, E. V.; Ovcharenko, V. I.; Mikhaleva, A. I.; Trofimov, B. A. Chem. Heterocycl. Compd. 2014, 50, 941. [Khim. Geterotsikl. Soedin. 2014, 1022.]

For this article in the English edition see DOI 10.1007/s10593-014-1548-6

Author Biography

Б. А. Трофимов, Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences

Борис Александрович Трофимов

Downloads

Published

2014-07-17

Issue

No. 7 (2014)

Section

Original Papers