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2,1-BENZOTHIAZINE 2,2-DIOXIDES. 8. SYNTHESIS AND STRUCTURE OF 2'-AMINO-2-OXO-1,2-DIHYDRO-6'H-SPIRO[INDOLE-3,4'-PYRANO[3,2-c][2,1]BENZOTHIAZINE]-3'-CARBONITRILE 5',5'-DIOXIDES

И. В. Украинец, Л. А. Петрушова, Н. Л. Березнякова, Я. Лю
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Abstract


1-R-1H-2,1-benzothiazine-4(3H)-one 2,2-dioxides in the presence of triethylamine easily participate in three-component condensation with N-substituted isatines and malononitrile producing 1-R',6-R-2'-amino-2-oxo-1,2-dihydro-6'H-spiro[indole-3,4'-pyrano[3,2-c][2,1]benzothiazine]-3'-carbonitrile 5',5'-dioxides in good yields. The reaction with 1-R-1H-2,1-benzothiazine-4(3H)-one 2,2-dioxide not substituted in position 1 follows an analogous path, but its products are triethylammonium salts of the corresponding spiro compounds.

How to Cite
Ukrainets, I. V.; Petrushova, L. A.; Bereznyakova, N. L.; Liu Yangyang Chem. Heterocycl. Compd. 2014, 50, 1346. [Khim. Geterotsikl. Soedin. 2014, 1459.]

For this article in the English edition see DOI 10.1007/s10593-014-1598-9


Keywords


4-oxo-3,4-dihydro-1H-2λ6,1-benzothiazine-2,2-dioхide; isatin; malonodinitrile; pyrano[3,2-c]benzothiazine; spiro[indole-3,4'-pyran]

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