Synthesis and cytotoxic activity of [benzo[<i>b</i>][1,4]oxazepino[7,6,5-<i>de</i>]quinolin-2-yl]-1,3-tropolones

Authors

  • Зыонг Нгиа Банг Thai Nguyen University of Sciences
  • Юрий А. Саяпин Scientific-Research Institute of Physical and Organic Chemistry, Southern Federal University; Southern Scientific Center, Russian Academy of Sciences
  • Хоанг Лам Thai Nguyen University of Sciences
  • Нгуен Данг Дык Thai Nguyen University of Sciences
  • Виталий Н. Комиссаров Scientific-Research Institute of Physical and Organic Chemistry, Southern Federal University

DOI:

https://doi.org/10.1007/2131

Keywords:

benzo[b][1, 4]oxazepino[7, 6, 5-de]quinolines, (benzo[b][1, 5-de]quinolin-2-yl)-1, 3-tropolones, halo derivatives, cytotoxicity

Abstract

We describe the synthesis of previously unknown halogenated derivatives of 2-(benzo[b][1,4]oxazepino[7,6,5-de]quinolin-2-yl)-1,3-tropolone. The MTT colorimetric assay was used to detect anticancer activity and inhibition of human epidermoid carcinoma (KB human epithelial carcinoma cell line) growth by 9,11-di(tert-butyl)-5-chloro-2,4-dimethyl-7Н-benzo[b][1,4]oxazepino[7,6,5-de]quinoline at IC50 93.7 µg/ml, and human breast carcinoma (MCF-7 cell line) growth by 2-[7-acetyl-9,11-di(tert-butyl)-5-chloro-4-methylbenzo[b][1,4]oxazepino[7,6,5-de]quinolin-2-yl]-5,6,7-trichloro-1,3-tropolone at IC50 12.96 µg/ml.

How to Cite
Bang, D. N.; Sayapin, Y. A.; Lam, H.; Duc, N. D.; Komissarov, V. N. Chem. Heterocycl. Compd. 2015, 51, 291. [Khim. Geterotsikl. Soedin. 2015, 51, 291.]

For this article in the English edition see DOI 10.1007/s10593-015-1697-2

 

Author Biographies

Юрий А. Саяпин, Scientific-Research Institute of Physical and Organic Chemistry, Southern Federal University; Southern Scientific Center, Russian Academy of Sciences

Юрий Анатольевич Саяпин

Старший научный сотрудник отдела физической и органической химии ЮНЦ РАН. Область интересов: органический синтез, механизмы реакций, хинолины, хиноксалины, индолины, бензимидазолы, бензоксазолы, спиропираны, хиноны, трополоны, 1,3-бензодиоксолы, диазепины, полициклические азотистые гетероциклы (производные хинолина, бензимидазола), гидрозоны и их комплексы с переходными металлами и др.

Виталий Н. Комиссаров, Scientific-Research Institute of Physical and Organic Chemistry, Southern Federal University

Виталий Николаевич Комиссаров

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Published

2015-02-05

Issue

Vol. 51 No. 3 (2015)

Section

Original Papers