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SYNTHESIS OF 1,3-DIHYDRO-2H-BENZO[d]AZEPIN-2-ONES

Andrejs Petuškovs, Kirill Shubin
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Abstract


Benzazepinones display a wide range of pharmacological activity, and are used for treatment of heart diseases, cancer,and Alzheimer's disease. They are also found in naturally-occurring alkaloids. Furthermore, benzazepinones are used as building blocks for synthesis of benzazepines useful for treatment of various neurological conditions. Structurally analogous dibenzazepinones are also found in pharmaceutically-relevant organic molecules. Here, methods of synthesis of benzazepinones – hydroamination, carbopalladation, amidation, Friedel–Crafts alkylation, rearrangements with cycle enlargement are reviewed.

How to Cite
Petuškovs, A.; Shubin, K. Chem. Heterocycl. Compd. 2016, 52, 84. [Khim. Geterotsikl. Soedin. 2016, 52, 84.]

For this article in the English edition see DOI 10.1007/s10593-016-1835-5

 


Keywords


Benzazepinone; Carbopalladation; Hydroamination; Friedel–Crafts alkylation; Amidation; Rearrangements with ring enlargement

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