SYNTHESIS OF 1,3-DIHYDRO-2<i>H</i>-BENZO[<i>d</i>]AZEPIN-2-ONES
DOI:
https://doi.org/10.1007/3020Keywords:
Benzazepinone, Carbopalladation, Hydroamination, Friedel–Crafts alkylation, Amidation, Rearrangements with ring enlargementAbstract
Benzazepinones display a wide range of pharmacological activity, and are used for treatment of heart diseases, cancer, and Alzheimer's disease. They are also found in naturally-occurring alkaloids. Furthermore, benzazepinones are used as building blocks for synthesis of benzazepines useful for treatment of various neurological conditions. Structurally analogous dibenzazepinones are also found in pharmaceutically-relevant organic molecules. Here, methods of synthesis of benzazepinones – hydroamination, carbopalladation, amidation, Friedel–Crafts alkylation, rearrangements with cycle enlargement are reviewed.
How to Cite
Petuškovs, A.; Shubin, K. Chem. Heterocycl. Compd. 2016, 52, 84. [Khim. Geterotsikl. Soedin. 2016, 52, 84.]
For this article in the English edition see DOI 10.1007/s10593-016-1835-5
