REACTION OF ENAMINO PYRROLIDIDE AND PIPERIDIDE OF 2,2-DIMETHYL-1,2,3,4-TETRAHYDROBENZ[<i>f</i>]ISOQUINOLINE SERIES WITH NINHYDRIN

Authors

  • Александр Г. Михайловский The Perm State Pharmaceutical Academy
  • Денис В. Корчагин Российский университет дружбы народов
  • Алексей С. Юсов ПГФА
  • Оксана В. Гашкова ПГФА

DOI:

https://doi.org/10.1007/3354

Keywords:

(Z)-2-(2, 2-диметил-2, 3-дигидробензо[f]изохинолин-4(1Н)-илиден)-1-(пирролидин-1-ил)этанон, нингидрин, аннелирование цикла индено[1, 2-b]пиррола, кипячение в присутствивии уксусной кислоты, гексациклическая система изохромено[4, 3-b]нафто[8, 7-a]индолизина.

Abstract

Interaction of (4Z)-2,2-dimethyl-4-(2-oxo-2-pyrrolidin-1-ylethylidene)-1,2,3,4-tetrahydrobenz[f]isoquinoline with ninhydrin leads to annulation of an indeno[1,2-b]pyrrole ring. An analogous product is formed by replacing of the pyrrolidine ring with the piperidine ring. Further heating of the obtained glycol in the presence of AcOH leads to rearrangement with the formation of benz[f]isochromeno[4',3':4,5]pyrrolo[2,1-a]isoquinoline hexacyclic system.

 

Authors: Alexander G. Mikhailovskii*, Denis V. Korchagin, Alexey S. Yusov, Oksana V. Gashkova

 

Author Biographies

Александр Г. Михайловский, The Perm State Pharmaceutical Academy

The chief of department for general chemistry, professor

Алексей С. Юсов, ПГФА

аспирант

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Published

2016-11-08

Issue

Vol. 52 No. 10 (2016)

Section

Letters to the Editor