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SYNTHESIS OF CHIRAL PHOSPHAZENE BASES

Martins Priede, Elina Priede, Jaan Saame, Ivo Leito, Edgars Suna
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Abstract


Air-stable and crystalline tetraaminophosphonium tetrafluoroborates possessing chiral, enantiomerically pure 1,2-diamine moiety have been synthesized by a three-step sequential one-pot approach. The tetrafluoroborate salts can be purified by recrystallization or chromatography and subsequently converted to the phosphazene bases by treatment with t-BuOK. Basicity values in tetrahydrofuran have been measured for the obtained phosphazene bases by means of spectrophotometric titration.

 

 


Keywords


phosphazene base; tetraaminophosphonium salts; basicity; one-pot synthesis; pKip value

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