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N-(HETERO)ARYL-2-IMIDAZOLINES: AN EMERGING PRIVILEGED MOTIF FOR CONTEMPORARY DRUG DESIGN

Mikhail Krasavin
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Abstract


The diverse biological activities of compounds containing N-(hetero)aryl-2-imidazoline moiety and methods to construct them are comprehensively reviewed for the first time. This intriguing non-flat, cyclic amidine motif clearly represents an emerging privileged structure.


Keywords


cyclodehydration; imidazoline N-arylation; lead-like compounds; privileged structures

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