Open Access Open Access  Restricted Access Subscription Access

ACTIVATION-FREE ONE-POT ALKYNYLATION–CYCLIZATION SYNTHESIS OF 2-SUBSTITUTED 4-AZAINDOLES AND INDOLES

Thomas J. J. Müller, Timo Lessing
Cover Image

Abstract


2-Substituted 4-azaindoles and indoles are rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation–cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

Keywords


4-azaindoles, heterocycles, indoles, alkynylation, cyclization, one-pot reaction.

Full Text: PDF Supplementary File(s): Supplementary material (1MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv